Basic Science

Ibrahim B.A., Wang H., Lesicko A.M.H., Bucci B., Paul K. and D.A. Llano (2017) Effect of temperature on FAD and NADH-derived signals and neurometabolic coupling in the mouse auditory and motor cortex. JPflügers Archiv - European Journal of Physiology Accepted, In Press. [pdf]

Patel M., Sons S., Yudintsev G., Lesicko A.M.H., Yang L., Taha G.A., Pierce S.M. and D.A. Llano (2017) Anatomical characterization of subcortical descending projections to the inferior colliculus in mouse. Journal of Comparative Neurology 525(4), 885-900. [pdf]

Caspary D.C. and D.A. Llano (2017) Auditory thalamic circuits and GABAA receptor function: Putative mechanisms in tinnitus pathology. Hearing Research 349:197-207. [pdf]

Lesicko A.M.H and D.A. Llano (2017) Impact of peripheral hearing loss on top-down auditory processing. Hearing Research 343, 4-13. [pdf]

Lesicko A.M.H., Hristova T.S., Maigler K.C.,and D.A. Llano (2016) Connectional modularity of top-down and bottom-up multimodal inputs to the lateral cortex of the inferior colliculus. Journal of Neuroscience 36(43), 11037-11050. [pdf]

Stebbings, KA, Choi HW., Ravindra A., Llano DA (2016) The impact of aging, hearing loss and body weight on mouse hippocampal redox state, measured in brain slices using fluorescence imaging. Neurobiology of Aging Jun;42:101-9. [pdf]

Paul K., Cauller L.J. and D.A. Llano (2016) Presence of a chaotic region at the sleep-wake transition in a simplified thalamocortical circuit model. Frontiers in Computational Neuroscience Sep 1;10:91. [pdf]

Stebbings, KA, Choi HW., Ravindra A., Caspary DM, Turner JG, Llano DA (2016) Aging-related changes in GABAergic inhibition in the mouse auditory cortex, measured using in vitro flavoprotein autofluoresence imaging. J. Physiology Jan 1;594(1):207-21. [pdf]

Willis A.M., Slater B.J., Gribkova E., Llano D. A. (2015) Open-loop organization of thalamic reticular nucleus and dorsal thalamus: A computational model J. of Neurophysiology Oct;114(4):2353-67 [pdf]

Slater B.J., Fan A., Stebbings K.A., Saif T., Llano D.A. (2015) Modification of a colliculo-thalamocortical mouse brain slice, incorporating 3-D printing of chamber components and multi-scale optical imaging. J. of Visualized Exp, Sep 18;(103) [pdf]

Ma C, Kenyon RF, Forbes A, Berger-Wolf T, Slater BJ, Llano DA (2015) Visualizing dynamic brain networks using a dual-representation. Eurographics Conference on Visualization (EuroVis), In Press. [pdf]

Fan, A, Stebbings KA, Llano DA and T Saif (2015) Stretch Induced Hyperexcitability of Mice Callosal Pathway. Frontiers in Cellular Neuroscience Aug 5;9:292. [pdf]

Llano D.A. (2015) “Thalamus and Language” In The Neurobiology of Language. Small S. and Hickok G. eds. Elsevier Publishers.

Stebbings K.A., Lesicko A.M.H. and D.A. Llano (2014) The auditory corticocollicular system: Molecular and circuit-level considerations (review). Hearing Research, Aug. 314C:51-59. [pdf]

Llano D.A., Slater B.J., Lesicko A.M.H. and K.A. Stebbings (2014) An auditory colliculo-thalamocortical brain slice preparation in mouse. Journal of Neurophysiology, Jan; 111(1):197-207. [pdf]

Hasson U., Llano D. A., Miceli G. and A.S. Dick (2014) Does it talk the talk? On the role of basal ganglia in emotive speech processing (commentary). Behavioral and Brain Sciences, Dec;37(6):556-7. [pdf]

Slater B.J., Willis A.M. and D.A. Llano (2013) Evidence for layer-specific differences in auditory corticocollicular neurons. Neuroscience. Jan 15;229:144-54. [pdf]

Llano D.A. (2012) Functional imaging of the thalamus in language. Brain and Language. Jul;126(1):62-72. [pdf]

Llano D.A. (2012) Voices below the surface:Is there a role for the thalamus in language? Brain and Language.
Jul;126(1):20-1. [pdf]

Llano D.A., Turner J. and D.M. Caspary (2012) Diminished cortical inhibition in an aging mouse model of chronic tinnitus. Journal of Neuroscience. Nov 14;32(46):16141-8. [pdf]

Yang S., Yang S., Cox C.L., Llano D.A., Feng A.S. (2012) Cell’s intrinsic biophysical properties play a role in the systematic decrease in time-locking ability of central auditory neurons. Neuroscience. 2012 Apr 19;208:49-57. [pdf]

Varela, C., Llano, D. A., & Theyel, B. B. (2012). An Introduction to in vitro slice approaches for the study of neuronal circuitry. In Neuronal Network Analysis (pp. 103-125). Humana Press. [pdf]

Theyel B.B., Llano D.A., Issa N., Mallik A. and S. M. Sherman. (2011) Laser photostimulation with flavoprotein autofluorescence imaging in vitro. Nature Protocols. Apr;6(4):502-8. [pdf]

Theyel B.B., Llano D.A. and S. M. Sherman. (2010) Evidence for a cortico-thalamocortical pathway for cortical communication. Nature Neuroscience. 13(1):84-8. [pdf]

Llano D.A. and S.M. Sherman (2009) Differences in intrinsic properties and local network connectivity of identified layer 5 and layer 6 adult mouse auditory corticothalamic neurons support a dual corticothalamic projection hypothesis. Cerebral Cortex. Dec;19(12):2810-26. [pdf]

Llano D.A., Theyel B.B., Mallik A., Sherman S.M. and N.P. Issa (2009) Rapid and sensitive mapping of long range connections in vitro using flavoprotein autofluorescence imaging combined with laser photostimulation. Journal of Neurophysiology. 101(6):3325-40 [pdf]

Lu E., Llano D.A., Sherman S.M. (2009) Different distributions of calbindin and calretinin immunostaining across the medial and dorsal divisions of the mouse medial geniculate body. Hearing Research 2009 Nov;257(1-2):16-23. [pdf]

Clinical & Translational

Llano, D.A., Mudar R., Bundela S. and D. Devanarayan (2017) A multivariate predictive modeling approach reveals a novel CSF peptide signature for both Alzheimer's Disease state classification and for predicting future disease progression. PLOS One Accepted, In Press. [pdf]

Wang, H, Kim, M, Normoyle, KP, Llano D (2016) Thermal regulation of the brain – an anatomical and physiological review for clinical neuroscientists. Frontiers in Neuroscience Jan 21;9:528. [pdf]

Llano D.A. and S.L. Small (2015) “Pharmacotherapy for Aphasia” In The Neurobiology of Language. Small S. and Hickok G. eds. Elsevier Publishers.

Llano D.A. and S.L. Small (2015) “Biological Approaches to Treatment of Aphasia” In Handbook on Adult Language Disorders, Hillis A., eds. Taylor & Francis Publishers.

Lenz RA, Pritchett YL, Berry SM, Llano DA, Han S, Berry DA, Sadowsky CH, Abi-Saab WM, Saltarelli MD. (2015) Adaptive, dose-finding phase 2 trial evaluating the safety and efficacy of ABT-089 in mild to moderate Alzheimer disease. Alzheimer Disease and Associated Disorders Jul-Sep;29(3):192-9. [pdf]

Llano D.A., Devanarayan V. and A. Simon (2013) Evaluation of plasma proteomic data for Alzheimer’s Disease state classification and for prediction of progression from mild cognitive impairment to Alzheimer Disease. Alzheimer Disease and Associated Disorders. Jul-Sep;27(3):233-43. [pdf]

Llano D.A., Li J., Lenz R.A., Ellis T., Cassar S., Groebe D., Gopalakrishnan M. and Waring J.F. (2012) Evidence for disrupted CNS inflammatory dynamics in Alzheimer’s Disease. Alzheimer Disease and Associated Disorders. Oct-Dec;26(4):322-8. [pdf]

Li J., Llano D.A., Ellis T., LeBlond D., Bhathena A., Jhee S.S., Ereshefsky L., Lenz R., Waring J.F. (2012) Effect of human cerebrospinal fluid sampling frequency on amyloid-β levels. Alzheimers and Dementia. Jul;8(4):295-303. [pdf]

Luo F., Rustay N.R., Ebert U., Hradil V.P., Cole T.B., Llano D.A., Mudd S.R., Zhang Y., Fox G.B., Day M. (2012) Characterization of 7- and 19-month-old Tg2576 mice using multimodal in vivo imaging: limitations as a translatable model of Alzheimer’s disease. Neurobiology of Aging. May;33(5):933-44. [pdf]

Llano D.A., Laforet G., Devanarayan V.; Alzheimer’s Disease Neuroimaging Initiative. (2011) Derivation of a new ADAS-cog composite using tree-based multivariate analysis: prediction of conversion from mild cognitive impairment to Alzheimer disease. Alzheimer Disease and Associated Disorders. Jan-Mar;25(1):73-84. [pdf]

Chin, C. L., Carr, R. A., Llano, D. A., Barret, O., Xu, H., Batis, J., ... & Fox, G. B. (2011). Pharmacokinetic Modeling and [123I] 5-IA-85380 Single Photon Emission Computed Tomography Imaging in Baboons: Optimization of Dosing Regimen for ABT-089. Journal of Pharmacology and Experimental Therapeutics, 336(3), 716-723. [pdf]

Luo, F., Rustay, N. R., Seifert, T., Roesner, B., Hradil, V., Hillen, H., Ebert, U., Severin, J.M., Cox, B.F., Llano, D.A., Day, M., Fox, G. B. (2010). Magnetic resonance imaging detection and time course of cerebral microhemorrhages during passive immunotherapy in living amyloid precursor protein transgenic mice. Journal of Pharmacology and Experimental Therapeutics, 335(3), 580-588. [pdf]

Small S.L. and Llano D.A. (2009) Biological Approaches to Aphasia Treatment. Current Neurology and Neuroscience Reports. Nov;9(6):443-50. [pdf]