Publications

Basic Science

Slater, B.J., Sons S.K., Yudintsev G., Lee C.M. and D.A. Llano (2018) Thalamocortical and intracortical inputs differentiate layer-specific mouse auditory corticocollicular neurons. Journal of Neuroscience, in press. [pdf]

Gribkova, E.D., Ibrahim, B.A. and D.A. Llano (2018). A novel mutual information estimator to measure spike train correlations in a model thalamocortical network. Journal of Neurophysiology, in press. [pdf]

Sottile S.Y., Hackett T.A., Cai R., Llano D.A., and D.M. Caspary (2017). Presynaptic neuronal nicotinic receptors differentially shape select inputs to auditory thalamus and are negatively impacted by aging. Journal of Neuroscience, 37(47):11377-11389. [pdf]

Ibrahim, B. A., Wang, H., Lesicko, A. M. H., Bucci, B., Paul, K., & Llano, D. A. (2017). Effect of temperature on FAD and NADH-derived signals and neurometabolic coupling in the mouse auditory and motor cortex. JPflügers Archiv - European Journal of Physiology, 469(12):1631-1649. [pdf]

Patel, M., Sons, S., Yudintsev, G., Lesicko, A. M. H., Yang, L., Taha, G. A., Pierce, S. M., & Llano, D. A. (2017). Anatomical characterization of subcortical descending projections to the inferior colliculus in mouse. Journal of Comparative Neurology, 525(4), 885-900. [pdf]

Lesicko, A. M. H., & Llano, D. A. (2017). Impact of peripheral hearing loss on top-down auditory processing. Hearing Research, 343, 4-13. [pdf]

Lesicko, A. M. H., Hristova, T. S., Maigler, K. C., & Llano, D. A. (2016). Connectional modularity of top-down and bottom-up multimodal inputs to the lateral cortex of the inferior colliculus. Journal of Neuroscience, 36(43), 11037-11050. [pdf]

Paul, K., Cauller, L. J., & Llano, D. A. (2016). Presence of a chaotic region at the sleep-wake transition in a simplified thalamocortical circuit model. Frontiers in Computational Neuroscience, 10. [pdf]

Caspary, D. C., & Llano, D. A. (2016). Auditory thalamic circuits and GABAA receptor function: Putative mechanisms in tinnitus pathology. Hearing Research. [pdf]

Stebbings, K. A., Choi, H. W., Ravindra, A., & Llano, D. A. (2016). The impact of aging, hearing loss and body weight on mouse hippocampal redox state, measured in brain slices using fluorescence imaging. Neurobiology of Aging, 42, 101-9. [pdf]

Stebbings, K. A., Choi, H. W., Ravindra, A., Caspary, D. M., Turner, J. G., & Llano, D. A. (2016). Aging-related changes in GABAergic inhibition in the mouse auditory cortex, measured using in vitro flavoprotein autofluoresence imaging. Journal of Physiology, 594(1), 207-21. [pdf]

Willis, A. M., Slater, B. J., Gribkova, E., & Llano, D. A. (2015). Open-loop organization of thalamic reticular nucleus and dorsal thalamus: A computational model. Journal of Neurophysiology, 114(4), 2353-67. [pdf]

Stebbings, K. A., Lesicko, A. M. H., & Llano, D. A. (2014). The auditory corticocollicular system: Molecular and circuit-level considerations (review). Hearing Research, 314, 51-9. [pdf]

Llano, D. A., Slater, B. J., Lesicko, A. M. H., & Stebbings, K. A. (2014). An auditory colliculo-thalamocortical brain slice preparation in mouse. Journal of Neurophysiology, 111(1):197-207. [pdf]

Slater, B. J., Willis, A. M., & Llano, D. A. (2013). Evidence for layer-specific differences in auditory corticocollicular neurons. Neuroscience, 229, 144-54. [pdf]

Llano, D. A., Turner, J., & Caspary, D. M. (2012). Diminished cortical inhibition in an aging mouse model of chronic tinnitus. Journal of Neuroscience, 32(46), 16141-8. [pdf]

Yang, S., Yang, S., Cox, C. L., Llano, D. A., & Feng, A. S. (2012). Cell’s intrinsic biophysical properties play a role in the systematic decrease in time-locking ability of central auditory neurons. Neuroscience, 208, 49-57. [pdf]

Varela, C., Llano, D. A., & Theyel, B. B. (2012). An Introduction to in vitro slice approaches for the study of neuronal circuitry. In Neuronal Network Analysis (pp. 103-125). Humana Press. [pdf]


Clinical & Translational

Swords G.M., Nguyen L.T., Mudar R.A. and D.A. Llano (2018). Auditory system dysfunction in Alzheimer Disease and its prodromal states: A review. Ageing Research Reviews Jul;44:49-59. [pdf]

Llano, D. A., Mudar, R., Bundela, S., & Devanarayan, D. (2017). A multivariate predictive modeling approach reveals a novel CSF peptide signature for both Alzheimer's Disease state classification and for predicting future disease progression. PLOS One Aug 3;12(8). [pdf]

Wang, H., Kim, M., Normoyle, K. P., Llano, D. (2016). Thermal regulation of the brain – an anatomical and physiological review for clinical neuroscientists. Frontiers in Neuroscience, 9. [pdf]

Llano, D. A., & Small, S. L. (2015). Pharmacotherapy for aphasia. In Hickok, G., & Small, S. (Eds.), The Neurobiology of Language. Elsevier Publishers.

Llano, D. A., & Small, S. L. (2015). Biological approaches to treatment of aphasia. In A. E., Hillis (Ed.), Handbook on Adult Language Disorders. Taylor & Francis Publishers.

Lenz, R. A., Pritchett, Y. L., Berry, S. M., Llano, D. A., Han, S., Berry, D. A., Sadowsky, C. H., Abi-Saab, W. M., & Saltarelli, M. D. (2015). Adaptive, dose-finding phase 2 trial evaluating the safety and efficacy of ABT-089 in mild to moderate Alzheimer disease. Alzheimer Disease and Associated Disorders, 29(3), 192-9. [pdf]

Llano, D. A., Devanarayan, V., & Simon, A. (2013). Evaluation of plasma proteomic data for Alzheimer’s Disease state classification and for prediction of progression from mild cognitive impairment to Alzheimer Disease. Alzheimer Disease and Associated Disorders, 27(3), 233-43. [pdf]

Llano, D. A., Li, J., Lenz, R. A., Ellis, T., Cassar, S., Groebe, D., Gopalakrishnan, M., & Waring, J. F. (2012). Evidence for disrupted CNS inflammatory dynamics in Alzheimer’s Disease. Alzheimer Disease and Associated Disorders, 26(4), 322-8. [pdf]

Li, J., Llano, D. A., Ellis, T., LeBlond, D., Bhathena, A., Jhee, S. S., Ereshefsky, L., Lenz, R., & Waring, J. F. (2012). Effect of human cerebrospinal fluid sampling frequency on amyloid-β levels. Alzheimers and Dementia, 8(4), 295-303. [pdf]

Luo, F., Rustay, N. R., Ebert, U., Hradil, V. P., Cole, T. B., Llano, D. A., Mudd, S. R., Zhang, Y., Fox, G. B., & Day, M. (2012). Characterization of 7- and 19-month-old Tg2576 mice using multimodal in vivo imaging: limitations as a translatable model of Alzheimer’s disease. Neurobiology of Aging, 33(5), 933-44. [pdf]

Llano, D. A., Laforet G., & Devanarayan V. (2011). Derivation of a new ADAS-cog composite using tree-based multivariate analysis: prediction of conversion from mild cognitive impairment to Alzheimer disease. Alzheimer Disease and Associated Disorders, 25(1), 73-84. [pdf]

Chin, C. L., Carr, R. A., Llano, D. A., Barret, O., Xu, H., Batis, J., Koren, A. O., Seibyl, J. P., Marsh, K. C., Tamagnan, G., Decker, M. W., Day, M., & Fox, G. B. (2011). Pharmacokinetic modeling and [123I] 5-IA-85380 single photon emission computed tomography imaging in baboons: optimization of dosing regimen for ABT-089. Journal of Pharmacology and Experimental Therapeutics, 336(3), 716-23. [pdf]

Luo, F., Rustay, N. R., Seifert, T., Roesner, B., Hradil, V., Hillen, H., Ebert, U., Severin, J.M., Cox, B.F., Llano, D.A., Day, M., & Fox, G. B. (2010). Magnetic resonance imaging detection and time course of cerebral microhemorrhages during passive immunotherapy in living amyloid precursor protein transgenic mice. Journal of Pharmacology and Experimental Therapeutics, 335(3), 580-8. [pdf]

Small, S. L., & Llano D. A. (2009). Biological approaches to aphasia treatment. Current Neurology and Neuroscience Reports, 9(6), 443-50. [pdf]