Basic Science

Ibrahim, B. A., Wang, H., Lesicko, A. M. H., Bucci, B., Paul, K., & Llano, D. A. (2017). Effect of temperature on FAD and NADH-derived signals and neurometabolic coupling in the mouse auditory and motor cortex. JPflügers Archiv - European Journal of Physiology, 469(12):1631-1649. [pdf]

Patel, M., Sons, S., Yudintsev, G., Lesicko, A. M. H., Yang, L., Taha, G. A., Pierce, S. M., & Llano, D. A. (2017). Anatomical characterization of subcortical descending projections to the inferior colliculus in mouse. Journal of Comparative Neurology, 525(4), 885-900. [pdf]

Lesicko, A. M. H., & Llano, D. A. (2017). Impact of peripheral hearing loss on top-down auditory processing. Hearing Research, 343, 4-13. [pdf]

Lesicko, A. M. H., Hristova, T. S., Maigler, K. C., & Llano, D. A. (2016). Connectional modularity of top-down and bottom-up multimodal inputs to the lateral cortex of the inferior colliculus. Journal of Neuroscience, 36(43), 11037-11050. [pdf]

Paul, K., Cauller, L. J., & Llano, D. A. (2016). Presence of a chaotic region at the sleep-wake transition in a simplified thalamocortical circuit model. Frontiers in Computational Neuroscience, 10. [pdf]

Caspary, D. C., & Llano, D. A. (2016). Auditory thalamic circuits and GABAA receptor function: Putative mechanisms in tinnitus pathology. Hearing Research. [pdf]

Stebbings, K. A., Choi, H. W., Ravindra, A., & Llano, D. A. (2016). The impact of aging, hearing loss and body weight on mouse hippocampal redox state, measured in brain slices using fluorescence imaging. Neurobiology of Aging, 42, 101-9. [pdf]

Stebbings, K. A., Choi, H. W., Ravindra, A., Caspary, D. M., Turner, J. G., & Llano, D. A. (2016). Aging-related changes in GABAergic inhibition in the mouse auditory cortex, measured using in vitro flavoprotein autofluoresence imaging. Journal of Physiology, 594(1), 207-21. [pdf]

Willis, A. M., Slater, B. J., Gribkova, E., & Llano, D. A. (2015). Open-loop organization of thalamic reticular nucleus and dorsal thalamus: A computational model. Journal of Neurophysiology, 114(4), 2353-67. [pdf]

Stebbings, K. A., Lesicko, A. M. H., & Llano, D. A. (2014). The auditory corticocollicular system: Molecular and circuit-level considerations (review). Hearing Research, 314, 51-9. [pdf]

Llano, D. A., Slater, B. J., Lesicko, A. M. H., & Stebbings, K. A. (2014). An auditory colliculo-thalamocortical brain slice preparation in mouse. Journal of Neurophysiology, 111(1):197-207. [pdf]

Slater, B. J., Willis, A. M., & Llano, D. A. (2013). Evidence for layer-specific differences in auditory corticocollicular neurons. Neuroscience, 229, 144-54. [pdf]

Llano, D. A., Turner, J., & Caspary, D. M. (2012). Diminished cortical inhibition in an aging mouse model of chronic tinnitus. Journal of Neuroscience, 32(46), 16141-8. [pdf]

Yang, S., Yang, S., Cox, C. L., Llano, D. A., & Feng, A. S. (2012). Cell’s intrinsic biophysical properties play a role in the systematic decrease in time-locking ability of central auditory neurons. Neuroscience, 208, 49-57. [pdf]

Varela, C., Llano, D. A., & Theyel, B. B. (2012). An Introduction to in vitro slice approaches for the study of neuronal circuitry. In Neuronal Network Analysis (pp. 103-125). Humana Press. [pdf]

Clinical & Translational

Swords G.M., Nguyen L.T., Mudar R.A. and D.A. Llano (2018). Auditory system dysfunction in Alzheimer Disease and its prodromal states: A review. Ageing Research Reviews Accepted, In Press. [pdf]

Llano, D. A., Mudar, R., Bundela, S., & Devanarayan, D. (2017). A multivariate predictive modeling approach reveals a novel CSF peptide signature for both Alzheimer's Disease state classification and for predicting future disease progression. PLOS One Aug 3;12(8). [pdf]

Wang, H., Kim, M., Normoyle, K. P., Llano, D. (2016). Thermal regulation of the brain – an anatomical and physiological review for clinical neuroscientists. Frontiers in Neuroscience, 9. [pdf]

Llano, D. A., & Small, S. L. (2015). Pharmacotherapy for aphasia. In Hickok, G., & Small, S. (Eds.), The Neurobiology of Language. Elsevier Publishers.

Llano, D. A., & Small, S. L. (2015). Biological approaches to treatment of aphasia. In A. E., Hillis (Ed.), Handbook on Adult Language Disorders. Taylor & Francis Publishers.

Lenz, R. A., Pritchett, Y. L., Berry, S. M., Llano, D. A., Han, S., Berry, D. A., Sadowsky, C. H., Abi-Saab, W. M., & Saltarelli, M. D. (2015). Adaptive, dose-finding phase 2 trial evaluating the safety and efficacy of ABT-089 in mild to moderate Alzheimer disease. Alzheimer Disease and Associated Disorders, 29(3), 192-9. [pdf]

Llano, D. A., Devanarayan, V., & Simon, A. (2013). Evaluation of plasma proteomic data for Alzheimer’s Disease state classification and for prediction of progression from mild cognitive impairment to Alzheimer Disease. Alzheimer Disease and Associated Disorders, 27(3), 233-43. [pdf]

Llano, D. A., Li, J., Lenz, R. A., Ellis, T., Cassar, S., Groebe, D., Gopalakrishnan, M., & Waring, J. F. (2012). Evidence for disrupted CNS inflammatory dynamics in Alzheimer’s Disease. Alzheimer Disease and Associated Disorders, 26(4), 322-8. [pdf]

Li, J., Llano, D. A., Ellis, T., LeBlond, D., Bhathena, A., Jhee, S. S., Ereshefsky, L., Lenz, R., & Waring, J. F. (2012). Effect of human cerebrospinal fluid sampling frequency on amyloid-β levels. Alzheimers and Dementia, 8(4), 295-303. [pdf]

Luo, F., Rustay, N. R., Ebert, U., Hradil, V. P., Cole, T. B., Llano, D. A., Mudd, S. R., Zhang, Y., Fox, G. B., & Day, M. (2012). Characterization of 7- and 19-month-old Tg2576 mice using multimodal in vivo imaging: limitations as a translatable model of Alzheimer’s disease. Neurobiology of Aging, 33(5), 933-44. [pdf]

Llano, D. A., Laforet G., & Devanarayan V. (2011). Derivation of a new ADAS-cog composite using tree-based multivariate analysis: prediction of conversion from mild cognitive impairment to Alzheimer disease. Alzheimer Disease and Associated Disorders, 25(1), 73-84. [pdf]

Chin, C. L., Carr, R. A., Llano, D. A., Barret, O., Xu, H., Batis, J., Koren, A. O., Seibyl, J. P., Marsh, K. C., Tamagnan, G., Decker, M. W., Day, M., & Fox, G. B. (2011). Pharmacokinetic modeling and [123I] 5-IA-85380 single photon emission computed tomography imaging in baboons: optimization of dosing regimen for ABT-089. Journal of Pharmacology and Experimental Therapeutics, 336(3), 716-23. [pdf]

Luo, F., Rustay, N. R., Seifert, T., Roesner, B., Hradil, V., Hillen, H., Ebert, U., Severin, J.M., Cox, B.F., Llano, D.A., Day, M., & Fox, G. B. (2010). Magnetic resonance imaging detection and time course of cerebral microhemorrhages during passive immunotherapy in living amyloid precursor protein transgenic mice. Journal of Pharmacology and Experimental Therapeutics, 335(3), 580-8. [pdf]

Small, S. L., & Llano D. A. (2009). Biological approaches to aphasia treatment. Current Neurology and Neuroscience Reports, 9(6), 443-50. [pdf]